Hydrochloric Acid → HCID 86645032, compound

Participants

Reaction Conditions

Reaction Steps

Following the general procedure for the synthesis of 2-R-5-(thiazol-2-ylamino)phenol, 2-bromothiazole (1.26 mL, 14.0 mmol), 5-amino-2-propylphenol (1.1 g, 7.0 mmol) and 37% HCl solution (1.21 mL, 14.0 mmol) in 10%, aqueous EtOH solution (20 mL) was stirred at 90° C. for 24 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 8/2) in 36% yield (588 mg).

Provenance & Evidence