HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 86645034, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Butene, 1-bromo-3-methyl- | HCID 70092 | — |
| Reactant | 3-[(4-Methyl-1,3-thiazol-2-yl)amino]phenol | HCID 53439480 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 86645034 | HCID 86645034 | 59% |
Reaction Steps
Following the procedure general for O-alkylation, Method A, a mixture of 3-(4-methylthiazol-2-ylamino)phenol (74 mg, 0.36 mmol) and K2CO3 (55 mg, 0.39 mmol) in acetone (3.6 mL) was treated with 4-bromo-2-methyl-2-butene (0.05 mL, 0.43 mmol). The reaction mixture was heated at reflux for 4 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 7/3) in 59% yield (58 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018209B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-dd9b30b2615548968c5f2ffa9e68c973 |
| Source note | uspto-grants-2015_04 |