Potassium Carbonate → HCID 86645038, compound

Participants

Reaction Steps

Following the general procedure for O-alkylation, Method A, a mixture of ethyl 2-(3-hydroxy-4-methylphenylamino)thiazole-4-carboxylate (80 mg, 0.29 mmol) and K2CO3 (44 mg, 0.32 mmol) in acetone (2.9 mL) was treated with 4-bromo-2-methyl-2-butene (0.037 mL, 0.32 mmol). The reaction mixture was heated at reflux for 4 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 7/3) in 57% yield (56 mg).

Provenance & Evidence