HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → N-(4-Methyl-3-(thiazol-2-ylmethoxy)phenyl)thiazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-(Bromomethyl)thiazole | HCID 15111478 | — |
| Reactant | 2-Methyl-5-(thiazol-2-ylamino)phenol | HCID 86645029 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N-(4-Methyl-3-(thiazol-2-ylmethoxy)phenyl)thiazol-2-amine | HCID 86645043 | 51% |
Reaction Steps
Following the general procedure for O-alkylation, Method B, a mixture of 2-methyl-5-(thiazol-2-ylamino)phenol (158 mg, 0.48 mmol) and Cs2CO3 (158 mg, 0.48 mmol) in acetone (4.4 mL) was treated with 2-bromomethylthiazole (86 mg, 0.48 mmol) at RT. Reaction control by TLC showed full conversion after 2.5 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 4/6) in 51% yield (75 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018209B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-7d89e332080343beacf850910a8d9131 |
| Source note | uspto-grants-2015_04 |