Cesium carbonate → HCID 15956106, compound

Participants

Reaction Steps

Following the general procedure for O-alkylation, Method B, a mixture of 2-chloro-5-(thiazol-2-ylamino)phenol (100 mg, 0.44 mmol) and Cs2CO3 (147 mg, 0.44 mmol) in acetone (4.4 mL) was treated with 2-bromomethylthiazole (88 mg, 0.44 mmol) at RT. Reaction control by TLC showed full conversion after 3 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 1/1) in 33% yield (47 mg).

Provenance & Evidence