反应详情

Following the general procedure for O-alkylation, Method B, a mixture of 2-hydroxy-4-(thiazol-2-ylamino)benzonitrile (70 mg, 0.32 mmol) and Cs2CO3 (105 mg, 0.32 mmol) in acetone (4.4 mL) was treated with 2-bromomethylthiazole (57 mg, 0.32 mmol) at RT. Reaction control by TLC showed full conversion after 4 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 4/6) in 8 yield (8 mg).

1. customReaction control by TLC
2. customafter 4 h