Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → N-(3-(benzyloxy)-4-methylphenyl)thiazol-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Methyl-5-(thiazol-2-ylamino)phenol | HCID 86645029 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | N-(3-(benzyloxy)-4-methylphenyl)thiazol-2-amine | HCID 86645044 | 58% |
반응 단계
Following the general procedure for O-alkylation, Method A, a mixture of 2-methyl-5-(thiazol-2-ylamino)phenol (70 mg, 0.34 mmol) and K2CO3 (52 mg, 0.32 mmol) in acetone (4.4 mL) was treated with benzyl bromide (58 mg, 0.34 mmol) at RT. Reaction control by TLC showed full conversion after 2 h 30 min. Subsequent benzyl bromide (20 microliter) and K2CO3 (20 mg) were added and stirred over night The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 3/1) in 58% yield (58 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09018209B2 |
| 출처 데이터셋 | uspto-grants-2015_04 |
| ORD ID | ord-7b3e3f54027845d1b23a9b8affdaa11f |
| 출처 메모 | uspto-grants-2015_04 |