HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1474003Generated: November 1, 2026
Cesium carbonate → N-(4-Chloro-3-(cyclopentenyloxy)phenyl)thiazol-2-amine
https://huagongshe.com/reaction/1474003
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-(Chloromethyl)cyclopent-1-ene | HCID 12914389 | — |
| Reactant | 2-Chloro-5-(thiazol-2-ylamino)phenol | HCID 86096006 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N-(4-Chloro-3-(cyclopentenyloxy)phenyl)thiazol-2-amine | HCID 86645047 | 25% |
Reaction Steps
Following the general procedure for O-allylation, Method B, a mixture 2-chloro-5-(thiazol-2-ylamino)phenol (88 mg, 0.39 mmol) and Cs2CO3 (127 mg, 0.39 mmol) in acetone was treated with 1-(chloromethyl)cyclopentene (60 mg, 0.39 mmol) at 0° C. The reaction mixture was heated to 60° C. and stirred for 3 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 8/2) in 25% yield (29 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09018209B2 |
|---|
| Source dataset | uspto-grants-2015_04 |
|---|
| ORD ID | ord-3da9da1998844294a504bc311b1f751f |
|---|
| Source note | uspto-grants-2015_04 |
|---|
