Cyclohexanol → HCID 15956113, compound

Participants

Reaction Steps

Following the procedure general for O-alkylation, Method C, 2-chloro-5-(thiazol-2-ylamino)phenol (70 mg, 0.31 mmol), 1-cyclohexanol (34 μM, 0.32 mmol), Ph3P (84 mg, 0.32 mmol) were suspended in THF (0.1 mL). The reaction flask was lowered into a sonication bath and sonicated for several minutes giving a clear and highly viscous solution. While sonication, DEAD (0.063 mL, 0.32 mmol) was added slowly. The reaction mixture was stirred for 1 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 7/3) in 5% yield (5 mg).

Provenance & Evidence