反应详情

温度

0 °C

5-Amino-o-cresol (1 g, 8.12 mmol) was dissolved in glacial acetic acid (4.1 mL) and H2O (8.41E) ata 35° C. The potassium cyanate solution was added slowly with stirring until a with precipitate of the product appears. The rest is added quickly with vigorous agitation. After 24 h, the reaction mixture was diluted with H2O, cooled to 0° C. and filtered with suction, washed with H2O and dried under high vacuum to afford the product (1.3 g, 99% yield).

1. customata 35° C
2. additionThe rest is added quickly with vigorous agitation
3. filtrationfiltered with suction
4. washwashed with H2O
5. customdried under high vacuum