Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromopyridine | HCID 7973 | — |
| Reactant | 5-Amino-2-chlorophenol | HCID 80676 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68488969 | HCID 68488969 | 24% |
Reaction Steps
Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-bromopyridine (0.13 mL, 1.4 mmol) and 5-amino-2-chlorophenol (100 mg, 0.7 mmol) in 10% aqueous EtOH (2 mL) was heated at 90° C. for 18 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 7/3) in 24% yield (36 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09018209B2 |
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| Source dataset | uspto-grants-2015_04 |
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| ORD ID | ord-5b442697cd3945218bdfc69889448da9 |
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| Source note | uspto-grants-2015_04 |
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