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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1474012Generated: November 1, 2026

2-Bromopyridine → HCID 68488969, compound

https://huagongshe.com/reaction/1474012

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-BromopyridineHCID 7973—
Reactant5-Amino-2-chlorophenolHCID 80676—
SolventEthanolHCID 702—
ProductHCID 68488969HCID 6848896924%

Reaction Conditions

Temperature90 °C

Reaction Steps

Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-bromopyridine (0.13 mL, 1.4 mmol) and 5-amino-2-chlorophenol (100 mg, 0.7 mmol) in 10% aqueous EtOH (2 mL) was heated at 90° C. for 18 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 7/3) in 24% yield (36 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09018209B2
Source datasetuspto-grants-2015_04
ORD IDord-5b442697cd3945218bdfc69889448da9
Source noteuspto-grants-2015_04