関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Bromopyridine | HCID 7973 | — |
| 反応物 | 4-Amino-2-hydroxybenzonitrile | HCID 12468682 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 68487935 | HCID 68487935 | 1% |
反応手順
Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-bromopyridine (0.21 mL, 2.2 mmol) and 4-amino-2-hydroxybenzonitrile (146 mg, 1.1 mmol) in 10% aqueous EtOH (5 mL) was heated at 90° C. for 18 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 1/1) in 1% yield (1.5 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09018209B2 |
|---|
| 出典データセット | uspto-grants-2015_04 |
|---|
| ORD ID | ord-7c34079573b4431bb711db520a74b787 |
|---|
| 出典メモ | uspto-grants-2015_04 |
|---|
