5-Amino-2-chlorophenol → HCID 68490264, compound

HRID 1474018Notes

Reaction equation

HRID 1474018 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[NH2:9][C:10]1[CH:11]=[CH:12][C:13]([Cl:17])=[C:14]([OH:16])[CH:15]=1>CCO>[Cl:17][C:13]1[CH:12]=[CH:11][C:10]([NH:9][C:2]2[N:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=2)=[CH:15][C:14]=1[OH:16]

Participants

4

Reactant 2

HCID 806765-Amino-2-chlorophenolHCID 116296072-Chloro-4-methylpyrimidine

Product 1

HCID 68490264HCID 68490264, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-chloro-4-methylpyrimidine (69 mg, 0.54 mmol) and 5-amino-2-chlorophenol (77 mg, 0.54 mmol) in 10% aqueous EtOH (3 mL) was heated at 90° C. for 18 h. The title compound was obtained in 74% yield a (94 mg) and used for the next step without additional purification.

Sources & evidence

ORD record
ord-1682e559d4974dd8a71c6f418ba608c0
Source dataset
uspto-grants-2015_04
Patent number
US09018209B2

Reaction notes

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