5-Amino-2-chlorophenol → 2-Chloro-5-[(4-methoxypyrimidin-2-yl)amino]phenol

Participants

Reaction Conditions

Reaction Steps

Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-chloro-4-methoxypyrimidine (87 mg, 0.60 mmol) and 5-amino-2-chlorophenol (86 mg, 0.60 mmol) in 10% aqueous EtOH (3 mL) was heated at 90° C. for 18 h. The title compound was obtained in 57% yield a (87 mg) and used for the next step without additional purification.

Provenance & Evidence