HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 15956115, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Butene, 1-bromo-3-methyl- | HCID 70092 | — |
| Reactant | HCID 68489605 | HCID 68489605 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 15956115 | HCID 15956115 | 48% |
Reaction Steps
Following the general procedure for O-alkylation of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-methyl-5-(pyridin-2-ylamino)phenol (67 mg, 0.33 mmol) and Cs2CO3 (113 mg, 0.35 mmol) in acetone (3.3 mL) was treated with 4-bromo-2-methyl-2-butene (0.038 mL, 0.33 mmol) at room temperature. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 8/2) in 48% yield (43 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018209B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-11230bc2c0a24bda84c86bd65b377d40 |
| Source note | uspto-grants-2015_04 |