HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 15956121, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Butene, 1-bromo-3-methyl- | HCID 70092 | — |
| Reactant | HCID 68488716 | HCID 68488716 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 15956121 | HCID 15956121 | 57% |
Reaction Steps
Following the general procedure for O-alkylation of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-methyl-5-(pyrimidin-2-ylamino)phenol (65 mg, 0.32 mmol) and Cs2CO3 (111 mg, 0.34 mmol) in acetone (3.2 mL) was treated with 4-bromo-2-methyl-2-butene (37 μL, 0.34 mmol) at room temperature. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 7/3) in 57% yield (50 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018209B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-e2f2cfa1cfac48079cb8bd97b684455c |
| Source note | uspto-grants-2015_04 |