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HRID1474024

反应详情

EQUATION

反应方程式

HRID 1474024 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[Cs+].[Cs+]
HCID10796

Cesium carbonate

CCs2O3

结构：CC(C)=CCBr
HCID70092

2-Butene, 1-bromo-3-methyl-

C5H9Br

结构：Oc1cc(Nc2ncccn2)ccc1Cl
HCID59474945

2-Chloro-5-[(pyrimidin-2-yl)amino]phenol

C10H8ClN3O

PRODUCTS

生成物

1
结构：CC(C)=CCOc1cc(Nc2ncccn2)ccc1Cl
HCID15956123

N-{4-Chloro-3-[(3-methylbut-2-en-1-yl)oxy]phenyl}pyrimidin-2-amine

C15H16ClN3O

收率 53%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Following the general procedure for O-alkylation of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-chloro-5-(pyrimidin-2-ylamino)phenol (30 mg, 0.14 mmol) and Cs2CO3 (47 mg, 0.14 mmol) in acetone (2.0 mL) was treated with 4-bromo-2-methyl-2-butene (16 μL, 0.14 mmol) at room temperature. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 7/3) in 53% yield (21 mg).