HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 11537036, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Butene, 1-bromo-3-methyl- | HCID 70092 | — |
| Reactant | 2-Chloro-5-[(4-methoxypyrimidin-2-yl)amino]phenol | HCID 68492690 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 11537036 | HCID 11537036 | 51% |
Reaction Steps
Following the general procedure for O-alkylation of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-chloro-5-(4-methoxypyrimidin-2-ylamino)phenol (54 mg, 0.22 mmol) and Cs2CO3 (70 mg, 0.22 mmol) in acetone (3 mL) was treated with 4-bromo-2-methyl-2-butene (25 μL, 0.22 mmol) at room temperature. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 8/2) in 51% yield (35 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018209B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-620fb4eda1a547c88416536c47fce033 |
| Source note | uspto-grants-2015_04 |