(R)-1-Benzyl-5-carboxy-2-pyrrolidinone → Ethyl 3-((R)-1-benzyl-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoate

HRID 1474147Notes

Reaction equation

HRID 1474147 reaction equation
[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH2:10][C@@H:9]1[C:14]([OH:16])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[CH2:18]([O:20][C:21](=[O:33])[CH:22]([OH:32])[CH:23]([NH3+:31])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH3:19]>>[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH2:10][C@@H:9]1[C:14]([NH:31][CH:23]([CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[CH:22]([OH:32])[C:21]([O:20][CH2:18][CH3:19])=[O:33])=[O:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 23390401(R)-1-Benzyl-5-carboxy-2-pyrrolidinoneHCID 86644788HCID 86644788, compound

Product 1

HCID 66644659Ethyl 3-((R)-1-benzyl-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoate

Procedure

The reaction was carried out in analogy to reaction step 20.1 of Example 20 by reacting (R)-1-benzyl-5-oxopyrrolidine-2-carboxylic acid and 4-ethoxy-3-hydroxy-4-oxo-1-phenylbutan-2-aminium chloride. ESI-MS [M+H]+=425.2.

Workup

  1. customThe reaction was carried out in analogy to reaction step 20.1 of Example 20

Sources & evidence

ORD record
ord-539901c8a38e4cceb68c892b2aa51997
Source dataset
uspto-grants-2015_04
Patent number
US09018206B2

Reaction notes

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