HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxobutanoic Acid → ethyl acetoacetate, sodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxobutanoic Acid | HCID 58 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl acetoacetate, sodium salt | HCID 85195 | 16,662.4% |
Reaction Steps
2-Oxo-butyric acid (10.0 g, 97.2 mmol) was dissolved in ethanol (100 mL) and p-toluene sulfonic acid mono hydrate (0.1 g) was added. The reaction mixture was heated to reflux for 48 h. After cooling the reaction mixture to room temperature, the ethanol was removed under reduced pressure to give 11.4 g of 2-oxo-butyric acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018228B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-6d98a364644d489cb42684cee9a59301 |
| Source note | uspto-grants-2015_04 |