HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1474257Generated: November 3, 2026
Tributylvinyltin → 3-Ethenyl-6-fluoro-2-methylbenzonitrile
https://huagongshe.com/reaction/1474257
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tributylvinyltin | HCID 81998 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | 3-Bromo-6-fluoro-2-methylbenzonitrile | HCID 66643852 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Ethenyl-6-fluoro-2-methylbenzonitrile | HCID 66643866 | — |
Reaction Steps
A mixture of 3-bromo-6-fluoro-2-methylbenzonitrile (8.8 g, 41 mmol), tributyl(vinyl)tin (14.3 g, 45.2 mmol), LiCl (5.20 g, 123 mmol) and Pd(PPh3)4 (2.3 g, 2.0 mmol) in toluene (200 mL) was heated at 100-110° C. under N2 overnight. The mixture was concentrated and the residue was purified by column chromatography to obtain 3-ethenyl-6-fluoro-2-methylbenzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09018211B2 |
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| Source dataset | uspto-grants-2015_04 |
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| ORD ID | ord-bd49f2007c0447449f5b21fd36c523a7 |
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| Source note | uspto-grants-2015_04 |
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