反应详情

A mixture of 5-bromo-4-iodo-2-benzofuran-1(3H)-one (1 g, 2.95 mmol), potassium vinyltrifluoroborate (474 mg, 3.54 mmol) and Pd(dppf)Cl2 (200 mg) in 20 mL of TEA and 20 mL of EtOH was heated to reflux under N2 for 2 hours. TLC showed complete reaction. Most of the solvent was removed, and the residue was dissolved in EtOAc (100 mL). The solution was washed with 0.1 N HCl, sodium bicarbonate, and brine, dried over sodium sulfate, filtered and concentrated to provide 5-bromo-4-vinyl-2-benzofuran-1(3H)-one.

1. temperaturewas heated
2. temperatureto reflux under N2 for 2 hours
3. customreaction
4. customMost of the solvent was removed
5. dissolutionthe residue was dissolved in EtOAc (100 mL)
6. washThe solution was washed with 0.1 N HCl, sodium bicarbonate, and brine
7. dry with materialdried over sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated