HCID 66643955, compound → HCID 66643986, compound

HRID 1474318Notes

Reaction equation

HRID 1474318 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[O:7][CH2:8][C:4]=2[C:3]=1[CH:12]=[CH2:13]>CO.[Pd]>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[O:7][CH2:8][C:4]=2[C:3]=1[CH2:12][CH3:13]

Participants

4

Reactant 1

HCID 66643955HCID 66643955, compound

Product 1

HCID 66643986HCID 66643986, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 5-bromo-4-vinyl-2-benzofuran-1(3H)-one (2.0 g, 8.37 mmol) and Pd/C (400 mg) in 50 mL of MeOH was stirred at rt. under H2 (1 atm) overnight, and then filtered. The filtrate was concentrated. The resulting oil was purified by column chromatography to give 5-bromo-4-ethyl-2-benzofuran-1(3H)-one.

Workup

  1. filtrationunder H2 (1 atm) overnight, and then filtered
  2. concentrationThe filtrate was concentrated
  3. customThe resulting oil was purified by column chromatography

Sources & evidence

ORD record
ord-f889cd940f6842d88b4956f441db3fce
Source dataset
uspto-grants-2015_04
Patent number
US09018211B2

Reaction notes

Loading…