HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1474394Generated: November 2, 2026
Hydrochloric Acid → Methyl 2-(3-bromo-2-hydroxyphenyl)acetate
https://huagongshe.com/reaction/1474394
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Methyl (2-hydroxyphenyl)acetate | HCID 89719 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-(3-bromo-2-hydroxyphenyl)acetate | HCID 12159074 | — |
Reaction Steps
To a solution of methyl (2-hydroxyphenyl)acetate (14.0 g, 84.3 mmol) in 100 mL of DCM was added diisopropyl-amine (1.70 g, 16.8 mmol) and NBS (15 g, 84.2 mmol) at 0° C. The mixture was stirred at 0° C. for 1 h. The reaction was poured into 1N HCl, extracted with DCM, and concentrated to give crude methyl (3-bromo-2-hydroxyphenyl)acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09018211B2 |
|---|
| Source dataset | uspto-grants-2015_04 |
|---|
| ORD ID | ord-b37d6e67194c4b12bc9c7c6dfaba023a |
|---|
| Source note | uspto-grants-2015_04 |
|---|
