HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1474395Generated: November 4, 2026
Methyl iodide → Methyl 2-(3-bromo-2-methoxyphenyl)acetate
https://huagongshe.com/reaction/1474395
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-(3-bromo-2-hydroxyphenyl)acetate | HCID 12159074 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 2-(3-bromo-2-methoxyphenyl)acetate | HCID 66643982 | — |
Reaction Steps
To a solution of methyl (3-bromo-2-hydroxyphenyl)acetate (18.7 g, 76.3 mmol) in 200 mL of DMF was added K2CO3 (52.7 g, 382 mmol), MeI (14.0 mL, 229 mmol). The mixture was stirred at 50° C. for 3 hours. The reaction solution was diluted with EtOAc and water. The organic layer was dried over anhydrous sodium sulfate and concentrated. The residue was purified column chromatography to give methyl [3-bromo-2-(methyloxy)phenyl]acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09018211B2 |
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| Source dataset | uspto-grants-2015_04 |
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| ORD ID | ord-fd16f6d6d6aa49649910aed9d0c7800a |
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| Source note | uspto-grants-2015_04 |
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