Sodium triacetoxyborohydride → HCID 66646349, compound

Participants

Reaction Steps

To a solution of 1-{[6-bromo-7-(methyloxy)-3,4-dihydro-1H-isochromen-1-yl]methyl}piperazine (100 mg, 0.3 mmol) in 5 mL of DCM was added 6-bromo-7-(methyloxy)-3,4-dihydro-1H-isochromene-1-carbaldehyde (81 mg, 0.30 mmol) and NaBH(OAc)3 (127 mg, 0.6 mmol). The mixture was stirred at room temperature overnight. The reaction mixture was diluted with DCM and washed with brine. The organic layer was dried over anhydrous Na2SO4 and concentrated. The residue was purified by prep-TLC to give 1,4-bis{[6-bromo-7-(methyloxy)-3,4-dihydro-1H-isochromen-1-yl]methyl}piperazine.

Provenance & Evidence