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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1474412Generated: October 30, 2026

4-(Oxiran-2-yl)benzonitrile → 4-[1-Hydroxy-2-[4-[2-hydroxy-2-(4-methyl-1-oxo-3H-isobenzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile

https://huagongshe.com/reaction/1474412

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Oxiran-2-yl)benzonitrileHCID 40494—
Reactant5-[(1R)-1-hydroxy-2-piperazin-1-ylethyl]-4-methyl-2-benzofuran-1(3H)-oneHCID 59568728—
Product4-[1-Hydroxy-2-[4-[2-hydroxy-2-(4-methyl-1-oxo-3H-isobenzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrileHCID 49802223—

Reaction Steps

4-[1-Hydroxy-2-[4-[2-hydroxy-2-(4-methyl-1-oxo-3H-isobenzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile was prepared in a similar fashion to that described for the synthesis of EXAMPLES 2C and 28-29 starting from 5-[(1R)-1-hydroxy-2-(piperazin-1-yl)ethyl]-4-methyl-2-benzofuran-1(3H)-one and 4-(oxiran-2-yl)benzonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09018211B2
Source datasetuspto-grants-2015_04
ORD IDord-13837860890844dc8555a46549c9d43f
Source noteuspto-grants-2015_04