Methyl chloroformate → HCID 131732762, compound

HRID 1474426Notes

Reaction equation

HRID 1474426 reaction equation
[Cl:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].Cl[C:14]([O:16][CH3:17])=[O:15]>>[Cl:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[C:4]([NH:5][C:14](=[O:15])[O:16][CH3:17])[CH:6]=[C:7]([Cl:9])[CH:8]=1

Participants

3

Reactant 2

HCID 6586Methyl chloroformateHCID 4643061HCID 4643061, compound

Product 1

HCID 131732762HCID 131732762, compoundYield 63%

Procedure

3,5-Dichloro-2-nitroaniline (600 mg, 2.90 mmol) was added with methyl chloroformate (25 mL, 0.12 M), and the mixture was subjected to a reaction for 18 hours under reflux. Methyl chloroformate was removed under reduced pressure, and the compound thus obtained was purified by column chromatography using 10% EtOAc/hexane to obtain the title compound (480 mg, yield: 63%).

Workup

  1. customthe mixture was subjected to a reaction for 18 hours
  2. temperatureunder reflux
  3. customMethyl chloroformate was removed under reduced pressure
  4. customthe compound thus obtained
  5. customwas purified by column chromatography

Sources & evidence

ORD record
ord-9b14cb19ceae408f98d515e7e8bc4f6d
Source dataset
uspto-grants-2015_04
Patent number
US09018233B2

Reaction notes

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