p-Fluorobenzoylacetonitrile → (2E)-3-(6-Fluoro-3-methyl-1H-indazol-5-yl)-2-[(4-fluorophenyl)carbonyl]prop-2-enenitrile
Reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][NH:8]2)=[CH:4][C:3]=1[CH:12]=O.[F:14][C:15]1[CH:20]=[CH:19][C:18]([C:21](=[O:25])[CH2:22][C:23]#[N:24])=[CH:17][CH:16]=1>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][NH:8]2)=[CH:4][C:3]=1/[CH:12]=[C:22](/[C:21]([C:18]1[CH:17]=[CH:16][C:15]([F:14])=[CH:20][CH:19]=1)=[O:25])\[C:23]#[N:24]Participants
3
Procedure
Following the procedure described for Example 2A, the title compound was prepared using 500 mg (2.81 mmol) 6-fluoro-3-methyl-1H-indazole-5-carbaldehyde (Example 3A) and 504 mg (3.09 mmol) 3-(4-fluorophenyl)-3-oxopropanenitrile to yield 768 mg (69% of th.) of the crude product (81% purity) which was used in the next step without further purification.
Sources & evidence
- ORD record
- ord-6ac460d41db3407b8fc75a8e38308c0b
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09018234B2
Reaction notes
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