Ammonium Acetate → HCID 178428417, compound

Participants

Reaction Steps

A mixture of 200 mg (0.89 mmol) (2E)-2-[(3-methyl-1H-indazol-5-yl)methylidene]-3-oxobutanenitrile (Example 2A), 159 mg (0.98 mmol) 3-(4-fluorophenyl)-3-oxopropanenitrile and 205 mg (2.66 mmol) ammonium acetate in ethanol/acetic acid (4:1 v/v, 11 ml) was heated to reflux overnight. After cooling, the reaction mixture was directly purified by preparative RP-HPLC (acetonitrile/water+0.1% TFA gradient) to afford 136 mg (41% of th.) of the racemic title compound.

Provenance & Evidence