Acetonitrile → HCID 66558749, compound

Participants

Reaction Steps

4.25 g (10 mmol) (Z)—N-[2-(diethylamino)ethyl]-2-methyl-7-(1,2-dihydro-5-fluoro-2-oxo-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indol-3-carboxamide was added to a mixture of 250 ml acetonitrile and 50 ml dichloromethane. The mixture was treated under ultrasonic sound to uniform dispersion. 1.81 g (12 mmol) L-mandelic acid was added and the solution was heated to reflux with stirring under nitrogen atmosphere. After reaction for 1 h, the resulting mixture was filtered while hot, and the filtrate was concentrated at reduced pressure to dryness, added to 30 ml anhydrous ethanol and treated under ultrasonic sound to uniform dispersion, then solution was filtered, and the filter cake was dried at 40° C. under vacuum, to give the title compound as orange solid (5.02 g, 8.7 mmol, yield 87%).

Provenance & Evidence