Acetic Anhydride → HCID 75238410, compound

Participants

Reaction Conditions

Reaction Steps

To a screw-capped test tube, N-(2-thienylcarbonyl)glycine (100 mg, 0.54 mmol), 5-hydroxymethylfuran-2-aldehyde (61 μL, 0.6 mmol), sodium acetate (45 mg, 0.54 mmol) and acetic anhydride (0.32 mL) were added. The test tube was sealed, and it was then stirred at an external temperature of 90° C. Three hours later, the temperature of the reaction solution was returned to room temperature, and water (1.5 mL) was then added thereto. The reaction mixture was extracted with ethyl acetate (5 mL) twice, and organic layers were then gathered. The thus obtained organic layer was washed with water (5 mL) twice, and then with a saturated saline (5 mL) once. Thereafter, the resultant was dried over anhydrous sodium sulfate and was then filtrated, followed by vacuum concentration. The obtained residue was purified by medium-pressure silica gel chromatography (hexane:ethyl acetate=9:1→4:6) and was then dried under reduced pressure, so as to obtain 31 mg of the above-captioned compound.

Provenance & Evidence