HCID 89806721, compound → HCID 89806719, compound

Participants

Reaction Steps

3.50 g of Compound 1 obtained in Synthesis Example 1 was dissolved in 15 mL of ethyl acetate, and 0.656 g of 5% palladium carbon (50% moisture content) was added thereto. Then, the inside of the reaction system was substituted with hydrogen, and the reaction system was stirred at room temperature overnight and subjected to hydrogenolysis. The 5% palladium carbon was filtered off, and washed with 80 mL of ethyl acetate. Then, the organic layers were combined, distilled under reduced pressure to remove ethyl acetate, and then dried under vacuum, thereby to give 2.58 g of Compound 2.

Provenance & Evidence