Trifluoroacetic acid → HCID 86729344, compound

Participants

Reaction Steps

To a solution of (2S,3R,4S,5S)-2-(4-chloro-3-(phenoxymethyl)phenyl)-6,6-bis(hydroxymethyl)-2-Methoxytetrahydro-2H-pyran-3,4,5-triol (8.0 g, 18.16 mmol) in DCM (45 mL) under nitrogen atmosphere was added TFA (4.17 mL, 54.4 mmol) at 0° C. The reaction mixture was warmed to r.t. and stirred for 3-4 h. After the completion of the reaction as confirmed by TLC, the reaction mixture was quenched with saturated solution of sodium bicarbonate. The crude compound was extracted with DCM (100 mL). The organic layer was separated, dried over Na2SO4 and concentrated in vacuo to afford crude title compound (7.45 g, 100%) as a white solid which was used without further purification for the next step.

Provenance & Evidence