Lithium hydroxide, monohydrate → HCID 89442839, compound

Participants

Reaction Steps

To a solution of (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(2-(methoxyimino)ethoxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate (100 mg, 0.161 mmol) in THF (0.6 mL), methanol (0.8 mL) and water (0.3 mL) was added lithium hydroxide monohydrate (13.5 mg, 0.322 mmol) at 0° C. The reaction was stirred at r.t. for 1 h. Volatiles were evaporated in vacuo and the residue obtained was purified by column chromatography (silica gel, 1:9 MeOH:DCM) to provide the title compound (70 mg, 96.2%) as white solid.

Provenance & Evidence