Water → HCID 117762239, compound

Participants

Reaction Steps

To a solution of (1R,2S,3S,4R,5S)-1-(acetoxymethyl)-5-(4-chloro-3-(4-(2-oxopropoxy)benzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triyl triacetate (180 mg, 0.28 mmol), in ethanol (8 mL) under nitrogen atmosphere, were added pyridine (0.114 mL, 1.42 mmol) and O-methylhydroxylamine hydrochloride (72 mg, 0.85 mmol). The reaction mixture was refluxed for 2 h. After completion of the reaction as confirmed by TLC, water (10 mL) was added to the reaction mixture and the crude compound was extracted with ethyl acetate (3×25 mL). The organic layers were dried over Na2SO4 and concentrated in vacuo to afford crude product which was purified by column chromatography (silica gel, 1.5:8.5 Acetone:Pet. Ether) to afford the title compound (120 mg, 63.8%).

Provenance & Evidence