Lithium hydroxide, monohydrate → HCID 117762022, compound

Participants

Reaction Steps

To a solution of (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(2-(methoxyimino)ethyl)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate (80 mg, 0.132 mmol) in THF (0.5 mL), methanol (0.7 mL) and water (0.3 mL) was added lithium hydroxide monohydrate (11 mg, 0.26 mmol) at 0° C. The reaction was stirred at r.t. for 1 h. Volatiles were evaporated in vacuo and the residue obtained was purified by column chromatography (silica gel, 0.5:9.5 MeOH:DCM) to provide the title compound (44 mg, 77%).

Provenance & Evidence