huagongshe.com
HRID1474633

反应详情

EQUATION

反应方程式

HRID 1474633 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：C1CCOC1
HCID8028

Tetrahydrofuran

C4H8O

结构：CON=C1CCC=C1Oc1ccc(Cc2cc([C@]34OC[C@](COC(C)=O)(O3)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]4OC(C)=O)ccc2Cl)cc1
HCID131732774

未命名化合物

结构：O.[Li]O
HCID178418351

未命名化合物

PRODUCTS

生成物

1
结构：CON=C1CCC=C1Oc1ccc(Cc2cc([C@]34OC[C@](CO)(O3)[C@@H](O)[C@H](O)[C@H]4O)ccc2Cl)cc1
HCID117762815

未命名化合物

收率 90.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of compound (1R,2S,3S,4R,5S)-1-(acetoxymethyl)-5-(4-chloro-3-(4-((5-(methoxyimino)cyclopent-1-en-1-yl)oxy)benzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triyl triacetate (110 mg, 0.16 mmol) in MeOH:THF:H2O (0.48 mL, 0.36 mL, 0.12 mL), LiOH.H2O (10.3 mg, 0.24 mmol) was added at 0° C. The reaction mixture was stirred for 1 h at r.t. After completion of the reaction as confirmed by TLC, the solvent was evaporated in vacuo. The crude compound obtained was purified by column chromatography (silica gel, 0.4:9.6 MeOH:DCM) to provide title compound (75 mg, 90.5%) as off-white solid.

WORKUP

后处理

  1. customAfter completion of the reaction
  2. customthe solvent was evaporated in vacuo
  3. customThe crude compound obtained
  4. customwas purified by column chromatography (silica gel, 0.4:9.6 MeOH:DCM)