Hydrogen Bromide → Phenacyl bromide

Participants

Reaction Steps

To a solution of acetophenone (500 mg, 4.16 mmol) in AcOH (20 mL) and catalytic amount of aq. HBr, 10% Br2/AcOH (2.12 mL) was added at 0° C. The reaction mixture was stirred for 2 h at r.t. After completion of the reaction as confirmed by TLC, the reaction mixture was diluted with ethylacetate (100 mL) and washed with water (20 mL) and brine (20 mL) successively. The organic layer was dried over Na2SO4 and the volatiles were evaporated in vacuo. The residue obtained was purified by column chromatography (silica gel, 1:9 EtOAc:hexane) to afford the title compound (825 mg, 4.1 mmol, 100%).

Provenance & Evidence