Water → HCID 117776457, compound

Participants

Reaction Steps

To a solution of compound (1R,2S,3S,4R,5S)-1-(acetoxymethyl)-5-(4-chloro-3-(4-(2-(methoxyimino)-2-phenylethoxy)benzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triyl triacetate (170 mg, 0.23 mmol) in MeOH:THF:H2O (0.7 mL, 0.5 mL, 0.17 mL), LiOH.H2O (14.7 mg, 0.35 mmol) was added at 0° C. The reaction mixture was stirred for 1 h at r.t. After completion of the reaction as confirmed by TLC, solvent was evaporated in vacuo. The residue obtained was diluted with ethylacetate (100 mL), washed with water (10 mL) and brine (10 mL). The organic layer was dried over Na2SO4 and the volatiles were evaporated in vacuo. The residue obtained was purified by column chromatography (silica gel, MeOH:DCM) to afford the title compound (80 mg, 0.14 mmol, 61.8%).

Provenance & Evidence