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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1474658Generated: November 1, 2026

2-Chloro-5-ethylpyrimidine → 2-((1S,2R)-2-(1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethanol

https://huagongshe.com/reaction/1474658

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-ethylpyrimidineHCID 3572763—
Reactant2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanolHCID 58128611—
Reactant2-((1S,2R)-2-(piperidin-4-yl)cyclopropyl)ethanolHCID 86711178—
Product2-((1S,2R)-2-(1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethanolHCID 117678496—

Reaction Steps

2-{(1S,2R)-2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanol was synthesized from 2-((1S,2R)-2-(piperidin-4-yl)cyclopropyl)ethanol according to the method described for 2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanol employing 2-chloro-5-ethylpyrimidine. MS (ESI) m/z 276.1 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09018224B2
Source datasetuspto-grants-2015_04
ORD IDord-38102a551b3a41aa9a6da7a196b3c927
Source noteuspto-grants-2015_04