HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azetidine → 1-(Azetidin-1-yl)-2-[4-(benzyloxy)-2-chlorophenyl]ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azetidine | HCID 10422 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-(4-(Benzyloxy)-2-chlorophenyl)acetic acid | HCID 4241746 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(Azetidin-1-yl)-2-[4-(benzyloxy)-2-chlorophenyl]ethanone | HCID 86711180 | — |
Reaction Steps
[4-(Benzyloxy)-2-chlorophenyl]acetic acid (0.52 g, 1.88 mmol) was dissolved in DMF (1 ml) and azetidine (0.161 g, 2.82 mmol), DIEA (0.99 ml, 5.64 mmol), and HATU (1.43 g, 3.76 mmol) added. The mixture was stirred at RT for 1 hr. The solution was loaded directly onto a Biotage RP C18 cartridge (30 g) and purified using a gradient eluant of 10-100% water:acetonitrile+0.05% formic acid. The volatiles were removed in vacuo to afford the title compound. LC/MS (m/z): 316 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018224B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-2e51c67a5fcf489f95ff095215ad7712 |
| Source note | uspto-grants-2015_04 |