HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → [4-(Benzyloxy)-2-cyanophenyl]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl [4-(benzyloxy)-2-cyanophenyl]acetate | HCID 86711182 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [4-(Benzyloxy)-2-cyanophenyl]acetic acid | HCID 70818555 | — |
Reaction Steps
A solution of tert-butyl [4-(benzyloxy)-2-cyanophenyl]acetate (0.48 g, 1.48 mmol) in DCM (7 ml) was treated with TFA (3.43 ml, 44.5 mmol) and the mixture stirred at RT for 30 min. The volatiles were removed in vacuo to afford the title compound. LC/MS (m/z): 268 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018224B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-27bc1bfbed1940b7acc61dd8bb0eddbd |
| Source note | uspto-grants-2015_04 |