Trifluoroacetic acid → (4-{2-[(1S,2R)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethoxy}-2,5-difluorophenyl)acetic acid

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Reaction Steps

Benzyl 4-{(1R,2S)-2-[2-(2-tert-butoxy-2-oxoethyl-2,5-difluorophenoxy)ethyl]cyclopropyl}piperidine-1-carboxylate (0.350 g, 0.661 ml) was dissolved in dichloromethane (1.5 ml) and TFA (1.5 ml) added. The mixture was stirred at RT for 3.5 h and the volatiles removed under vacuum to afford the title compound. LC/MS (m/z): 474.3 (M+H)+.

Provenance & Evidence