反应详情

To a solution of benzyl 4-[(1R,2S)-2-(2-{4-[2-(dimethylamino)-2-oxoethyl]-2,5-difluorophenoxy}ethyl)cyclopropyl]piperidine-1-carboxylate (226 mg, 0.451 mmol) in 2 ml anhydrous methanol at RT was added 10% palladium on carbon (25.0 mg). The reaction mixture was stirred under a hydrogen atmosphere for 2 hours. The slurry was filtered through celite, and the filtrate concentrated to afford the title compound. LC/MS (m/z): 368.4 (M+H)+.

1. filtrationThe slurry was filtered through celite
2. concentrationthe filtrate concentrated