反应详情

2,3-O-isopropylidene-D-erythronolactone (1.04 g, 6.42 mmol) was dissolved in toluene (20 ml), followed by the addition of 1 M diisobutylammonium hydride (DIBAL)/THF to the solution at −78° C. The reaction mixture was stirred at the same temperature for 30 min and methanol was slowly added until the reaction terminated. The suspension was filtered through a Celite filter and the filtrate was extracted with ethyl acetate and water, followed by silica gel column chromatography using a mixture of hexane:ethylacetate (3:1, v/v) to give the object compound in syrup form (1.94 g, 96%).

1. customterminated
2. filtrationThe suspension was filtered through a Celite
3. filtrationfilter
4. extractionthe filtrate was extracted with ethyl acetate and water
5. additiona mixture of hexane:ethylacetate (3:1
6. customv/v) to give the object compound in syrup form (1.94 g, 96%)