HCID 22061087, compound → HCID 22060429, compound

HRID 1475023Notes

Reaction equation

HRID 1475023 reaction equation
C([O:3]C(C=NC1C=C(NC2N=C(NC3C=CC=C(O)C=3)C(F)=CN=2)C=CC=1)=O)C.[F:30][C:31]1[C:32]([NH:53][C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([OH:60])[CH:55]=2)=[N:33][C:34]([NH:37][C:38]2[CH:43]=[CH:42][CH:41]=[C:40]([N:44]=[CH:45][C:46]([NH:48][CH2:49][CH2:50]NC)=[O:47])[CH:39]=2)=[N:35][CH:36]=1>>[F:30][C:31]1[C:32]([NH:53][C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([OH:60])[CH:55]=2)=[N:33][C:34]([NH:37][C:38]2[CH:43]=[CH:42][CH:41]=[C:40]([N:44]=[CH:45][C:46]([NH:48][CH2:49][CH2:50][OH:3])=[O:47])[CH:39]=2)=[N:35][CH:36]=1

Participants

3

Reactant 2

HCID 22061087HCID 22061087, compoundHCID 57472942HCID 57472942, compound

Product 1

HCID 22060429HCID 22060429, compound

Procedure

In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-[3-(N-morpholinoethyleneamino)carbonylmethyleneaminophenyl]-2,4-pyrimidinediamine, N2-(3-ethoxycarbonylmethyleneaminophenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine and N-methyl-ethylen-1,2-diamine were reacted to prepare 5-fluoro-N4-(3-hydroxyphenyl)-N2-[3-[(N-methylamino)ethylamino]carbonylmethyleneaminophenyl]-2,4-pyrimidinediamine. LCMS: ret. time: 12.31 min.; purity: 94.7%; MS (m/e): 426.01 (MH+).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-859446b11f5c4802a6608198907079b4
Source dataset
uspto-grants-2015_04
Patent number
US09018204B1

Reaction notes

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