Ammonia → 3-methyl-1H-1,2,4-triazole-5-carboxamide

HRID 1475221Notes

Reaction equation

HRID 1475221 reaction equation
[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([O:9]CC)=O)[N:3]=1.[NH3:12]>CO>[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([NH2:12])=[O:9])[N:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 10464537ethyl 3-methyl-1H-1,2,4-triazole-5-carboxylate

Product 1

HCID 122201083-methyl-1H-1,2,4-triazole-5-carboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

Ethyl 5-methyl-1H-1,2,4-triazole-3-carboxylate (3.0 g, 19.3 mmol) is placed in a sealed tube that is then charged with a solution of 7N NH3 in MeOH (40 mL). The reaction is stirred at 50° C. for 24 h. The solvent was then removed under reduced pressure and the crude material was used directly for the next step without further purification. MS (ES+) C4H6N4O requires: 126. found: 127 [M+H]+.

Workup

  1. customThe solvent was then removed under reduced pressure
  2. customthe crude material was used directly for the next step without further purification

Sources & evidence

ORD record
ord-a9f6569fffba48f9b1af211c473f4130
Source dataset
uspto-grants-2015_04
Patent number
US09018380B2

Reaction notes

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