Cesium carbonate → HCID 86711927, compound

Participants

Reaction Steps

A mixture of 5-(5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole (Intermediate B, 2 g, 6.43 mmol), 1-(bromomethyl)-3-nitrobenzene (1.39 g, 6.43 mmol) and Cs2CO3 (4.2 g, 12.9 mmol) in DMF (40 mL) was stirred at RT for 16 h. The mixture was then diluted with H2O and extracted with EtOAc (3×200 mL). The combined organic extracts were washed with H2O (20 mL) and brine (20 mL), dried (Na2SO4), and concentrated under reduced pressure to afford the title compound as a yellow solid (1.8 g, 56.4%). LC-MS (ES+) C19H13F3N6O4 requires: 446. found: 447 (M+H)+.

Provenance & Evidence