Hydrazine hydrate (1:1) → HCID 86711938, compound

Participants

Reaction Steps

To a solution of ethyl 4-(4-(trifluoromethoxy)phenyl)thiazole-2-carboxylate (10.0 g, 31.5 mmol) in MeOH (80 mL) was added hydrazine hydrate (1.95 g, 33.1 mmol; 85%) dropwise over 15 minutes, and the resulting mixture was stirred for a further 16 h at RT. The mixture was then concentrated under reduced pressure to half volume, and H2O (30 mL) was added. A white solid precipitated, was filtered, washed with H2O (3×30 mL) and dried to afford the title compound as a white solid (9.6 g, 100%). MS (ES+) C11H8F3N3O2S requires: 303. found: 304[M+H]+.

Provenance & Evidence